Academia.edu no longer supports Internet Explorer.
To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser.
2006
We developed a computational method to characterize aneuploidy in tumor samples based on coordinated aberrations in expression of genes localized to each chromosomal region. We summarized the total level of chromosomal aberration in a given tumor in a univariate measure termed total functional aneuploidy. We identified a signature of chromosomal instability from specific genes whose expression was consistently correlated with total functional aneuploidy in several cancer types.
2012 •
Nature Communications
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma2014 •
Nature Communications
Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer2015 •
The British Journal of Ophthalmology
Does radiotherapy have a role in the management of thyroid orbitopathy? View 12002 •
Nature Medicine
Subclonal diversification of primary breast cancer revealed by multiregion sequencing2015 •
Cancer discovery
The genomic landscape of pediatric Ewing sarcoma2014 •
Pediatric Ewing sarcoma is characterized by the expression of chimeric fusions of EWS and ETS family transcription factors, representing a paradigm for studying cancers driven by transcription factor rearrangements. In this study, we describe the somatic landscape of pediatric Ewing sarcoma. These tumors are among the most genetically normal cancers characterized to date, with only EWS-ETS rearrangements identified in the majority of tumors. STAG2 loss, however, is present in more than 15% of Ewing sarcoma tumors; occurs by point mutation, rearrangement, and likely nongenetic mechanisms; and is associated with disease dissemination. Perhaps the most striking finding is the paucity of mutations in immediately targetable signal transduction pathways, highlighting the need for new therapeutic approaches to target EWS-ETS fusions in this disease. We performed next-generation sequencing of Ewing sarcoma, a pediatric cancer involving bone, characterized by expression of EWS-ETS fusions. W...
2011 •
Genome Biology
Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays2009 •
Genes, Chromosomes and Cancer
Mitotic recombination of chromosome arm 17q as a cause of loss of heterozygosity of NF1 in neurofibromatosis type 1-associated glomus tumors2012 •
2014 •
Journal of Cancer Metastasis and Treatment
Unmasking tumor heterogeneity and clonal evolution by single-cell analysis2015 •
The American Journal of Pathology
Aneuploidy Arises at Early Stages of Apc-Driven Intestinal Tumorigenesis and Pinpoints Conserved Chromosomal Loci of Allelic Imbalance between Mouse and Human2007 •
BMC Bioinformatics
Towards accurate characterization of clonal heterogeneity based on structural variation2014 •
Clinical cancer research : an official journal of the American Association for Cancer Research
Mutational landscape of aggressive cutaneous squamous cell carcinoma2014 •
Cancer research
Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer2014 •
Scientific reports
BACOM2.0 facilitates absolute normalization and quantification of somatic copy number alterations in heterogeneous tumor2015 •
Systematic biology
Cancer evolution: mathematical models and computational inference2015 •
Genome Research
Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution2015 •
2013 •
2009 •
2014 •
Journal of translational medicine
BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma2015 •
Cancer discovery
EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing2014 •
Nature communications
Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer2015 •
2012 •
European urology
Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas2015 •
Clinical Gastroenterology and Hepatology
Refining Molecular Analysis in the Pathways of Colorectal Carcinogenesis2005 •
Breast Cancer Research
Evaluation of ultra-deep targeted sequencing for personalized breast cancer care2013 •
Clinical cancer research : an official journal of the American Association for Cancer Research
Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups2015 •
Nature Genetics
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer2012 •
Genes, Chromosomes and Cancer
Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGH2007 •
2006 •
2014 •
Genes, Chromosomes and Cancer
Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas2015 •